Matters arising: statistical overfitting and outcome discordance undermine the claimed superiority of T2 fusion for shoulder balance in adolescent idiopathic scoliosis

出现的问题:统计过度拟合和结果不一致削弱了T2融合术在青少年特发性脊柱侧弯肩部平衡方面所宣称的优越性。

阅读:1

Abstract

A recent study by Li et al. evaluated shoulder balance in Lenke type 2 adolescent idiopathic scoliosis and concluded that the ratio of proximal to main thoracic curve (PTC/MTC) correction independently predicts postoperative shoulder imbalance (PSI), further suggesting that fusion to T2 provides superior shoulder balance compared with fusion to T3/4. A re-examination of the study's methodology indicates that these conclusions are compromised by two principal limitations: (1) statistical overfitting and quasi-separation within the multivariable logistic regression model used to identify predictors of PSI, and (2) lack of alignment between radiographic findings and patient-reported outcomes. These methodological and interpretive issues are well recognized in the clinical and statistical literature, and addressing them is essential for ensuring valid inference and accurate clinical interpretation.

特别声明

1、本页面内容包含部分的内容是基于公开信息的合理引用;引用内容仅为补充信息,不代表本站立场。

2、若认为本页面引用内容涉及侵权,请及时与本站联系,我们将第一时间处理。

3、其他媒体/个人如需使用本页面原创内容,需注明“来源:[生知库]”并获得授权;使用引用内容的,需自行联系原作者获得许可。

4、投稿及合作请联系:info@biocloudy.com。