Abstract
Alzheimer's disease (AD) and type 2 diabetes mellitus (T2D) are highly prevalent aging-related diseases associated with significant morbidity and mortality. Patients with T2D have an increased risk to develop AD, while glucose metabolism abnormalities are frequent among AD patients. Epidemiological studies and the results of basic science point to possible shared pathophysiology between T2D and AD. Co-occurrence of diabetes mellitus and AD was noticed long time ago. However, more recent data reveal that comorbidity of AD and T2D occurs significantly more frequently than is expected by chance alone. In spite of the high importance of this association, the inter-relational mechanisms are unclear. The results of recent investigations indicate that caveolin-1 (CAV-1)-a small membrane protein involved in signaling pathways-may play an important role in this association. Preliminary results pointing to this role of CAV-1 were collected after examination of patients with AD. Subsequent investigation in an animal model confirmed these initial observations. The involvement of CAV-1 in T2D and AD may be mediated by cellular organelles, including mitochondria and endoplasmic reticulum.