Mitochondrial respiration inhibitor enhances the anti-tumor effect of high-dose ascorbic acid in castration-resistant prostate cancer
线粒体呼吸抑制剂增强高剂量抗坏血酸在去势抵抗性前列腺癌中的抗肿瘤作用
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作者：Jia Qiu #, Tianhong Yang #, Yali Long #, Peng He, Wanqing Shen, Bing Zhang, Xinchong Shi, Lei Peng, Zhoulei Li, Xiangsong Zhang
Key messages
Ascorbic acid inhibits tumor growth by inducing ROS generation. As a mitochondrial respiration inhibitor, metformin inhibits cellular oxygen consumption rate to improve oxygenation of prostate cancer. Metformin enhances anti-tumor effect of ascorbic acid by increasing ROS content. Ascorbic acid inhibits the mTOR expression via PI3K-AKT pathway, and metformin inhibits the mTOR expression by inhibiting AMPK signaling in prostate cancer cells.
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