Effects of deep brain stimulation on personality and executive function in Parkinson's disease

深部脑刺激对帕金森病患者人格和执行功能的影响

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Abstract

Parkinson's disease (PD) is associated with cognitive and personality changes that extend beyond its characteristic motor symptoms. OBJECTIVE: To analyze the effects of subthalamic nucleus deep brain stimulation (STN-DBS) on executive function (EF) and personality (The Five-Factor Model - FFM) in PD patients, comparing outcomes between those treated solely with medication and those receiving both medication and STN-DBS. METHODS: A total of 69 participants were divided into three groups: DBS, medication, and control. Evaluations included inventories, tests, and scales, with results summarized in tables highlighting sociodemographic variables and screening outcomes. RESULTS: Cognitive assessments indicated that the DBS group exhibited slightly lower cognitive scores compared to the medication group. Personality differences were minimal, with only extraversion demonstrating significance. CONCLUSION: STN-DBS did not have a significant impact on executive functions or personality traits in patients with PD. These results highlight the importance of considering broader cognitive and neuropsychiatric factors when evaluating patient outcomes following DBS.

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