Abstract
BACKGROUND: This study investigated the association between triglyceride/high-density lipoprotein cholesterol (TG/HDL-C), total cholesterol/high-density lipoprotein cholesterol (TC/HDL-C) and clinical outcomes in patients with peritoneal dialysis (PD) through the present prospective cohort study. METHODS: This study is an observational analysis based on PD Telemedicine-assisted Platform Cohort Study. The lipid data was defined as the average levels for the first 3 months after receiving PD, including TG, TG and HDL-C. The primary outcome was all-cause mortality, and the secondary outcomes were major adverse cardiovascular events (MACE), modified MACE+ and hemodialysis transfer. RESULTS: A total of 5875 PD patients were enrolled. By cubic spline regression analysis, the cut-off value of TG/HDL-C and TC/HDL-C were 1.25 and 4.20, respectively. During the follow-up time, 1098 (7.75/100 person-years) patients died, and the leading cause of mortality was cardiovascular diseases [686 (4.85/100 person-years)]. MACE and modified MACE+ occurred in 845 (6.09/100 person-years) and 1459 (10.83/100 person-years) patients, respectively. There were 719 patients (5.08/100 person-years) transferred to hemodialysis. The incidence of all-cause mortality, MACE and modified MACE+ were significant higher in groups with elevated TG/HDL-C and TC/HDL-C (P < .001). CONCLUSIONS: Among patients treated with PD, the elevated TG/HDL-C and TC/HDL-C were independently associated with increased risk of mortality and cardiovascular events.