Abstract
Malaria is a tropical disease secondary to the Plasmodium parasite with clinical features ranging from febrile illness to acute renal failure and further renal sequelae. We present a case of a woman minimal change disease secondary to Plasmodium falciparum who developed nephrotic range proteinuria and ultimately acute renal failure requiring renal replacement therapy. With proper treatment of her malarial infection as well as long-term renal replacement therapy, she made a full recovery. This case is one of the few cases that highlight the association between severe malarial infections and renal failure necessitating long-term hemodialysis.