Abstract
Active pharmaceutical ingredients (APIs) and their intermediate residues have recently been considered a serious concern. Among technologies, bio-electrochemical technologies (BETs) have stimulated the production of bio-electrical energy. This review aims to examine the benefit and mechanism of BETs on the degradation of high-consumption pharmaceutical compounds, including antibiotic, anti-inflammatory, and analgesic drugs, and the stimulation of enzymes induced in a bioreactor. Moreover, intermediates and the proposed pathways of pharmaceutical compound biodegradation in BETs are to be explained in this review. According to studies performed exclusively, the benefit of BETs is using bio-electroactive microbes to mineralize recalcitrant pharmaceutical contaminants by promoting enzyme activity and energy. Since BETs use the electron transfer chain between bio-anode/-cathode and pharmaceuticals, the enzyme activity is essential in the oxidation and reduction of phenolic rings of drugs and the ineffective detoxification of effluent from the treatment plant. This study is suggested a vital and influential role of BETs in mineralizing and enzyme induction in bioreactors. Eventually, a content of future developments or outlooks of BETs are propounded to improve the pharmaceutical industries' wastewater problems.