Abstract
A 3.9-year-old female African pygmy hedgehog (Atelerix albiventris) had a firm, tan-colored mass with an uneven surface arising from the mandibular salivary gland. A histopathologic examination revealed that the mass was composed of neoplastic proliferation of epithelial and spindle cells. The neoplastic spindle cells showed positive for vimentin, smooth muscle actin, calponin and cytokeratin 14 and, negative for cytokeratin 19, suggesting that spindle cells were derived from myoepithelial cells. Based on the histological findings and immunohistochemistry results, the mass was diagnosed as pleomorphic adenoma. Pleomorphic adenoma is the most common benign tumor found in human salivary glands, but it is rare in animals. To the best of our knowledge, this is the first report of pleomorphic adenoma in hedgehogs.