Abstract
This study introduces a framework that integrates AI-driven Game-Based Language Teaching (GBLT) with advanced neuroscience to transform language education for visually impaired learners. Built on the principles of neuroplasticity and epigenetics, the approach leverages educational psychology with the help of adaptive AI to deliver personalized, gamified learning experiences that reshape neural pathways, improve memory retention, and strengthen emotional resilience. By fostering low-stress, immersive environments, it triggers positive epigenetic changes, enhancing long-term cognitive flexibility. This method article presents an interdisciplinary inclusive scientific framework that unites gamification, technology, epigenetics, and neuroscience, empowering learners and promoting sustainable well-being, while laying the groundwork for intergenerational academic and personal growth.•To propose a teaching methodology that aims to bridge gaps in traditional and game based language teaching by integrating neuroscience and epigenetics, creating an inclusive framework tailored to meet the unique needs of visually impaired learners.•The method emphasizes creating stress-free, rewarding educational environments that induce neural and epigenetic changes. These changes optimize gene expression to improve retention, emotional resilience, and cognitive flexibility, ensuring both immediate academic success and lifelong developmental benefits for diverse learners.•This framework promotes cognitive, emotional, social and biological development alongside language acquisition giving a holistic mode of growth.