A method for assessing carcinogenic risk of air fine particle-associated polycyclic aromatic hydrocarbons by considering bioaccessibility in lung fluids

一种通过考虑肺液中的生物可及性来评估空气细颗粒物相关多环芳烃致癌风险的方法

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Abstract

This study was conducted to evaluate the inhalation carcinogenic risk of PAHs in biochar fine particles using total concentration-based assessment approach and bioaccessibility-based assessment approach. Only limit PAHs in particles can be released in simulated lung fluids, leading to a low bioaccessibility (only ranging from 0.34% to 1.48% for biochar fine particles and from 3.21% to 44.2% for PM(2.5)), which would significantly affect health risk assessment. Therefore, bioaccessibility should always be favored over more traditional evaluations based on total concentration, while evaluating inhalation health risks of biochar-bound PAHs. To prove the broad applicability of bioaccessibility-based assessment approaches, we also compared health risk of actual atmospheric particles (PM(2.5) collected from Nanjing, China) using total concentration-based approaches and bioaccessibility-based approaches. •Proposed bioaccessibility-based approaches for assessing biochar risk are more accurate than traditional total concentration-based approaches;•Proposed bioaccessibility-based approaches can be applied to health risk assessment of actual air particles;•A more practical method was proposed to evaluate the bioaccessibility of PAHs in biochar fine particles or other specific component of atmospheric particle matters: using wet sieving method to prepare fine particles, using volatile organic solvent-drying method to load (14)C-PAHs on fine particles, and using desorption experiments to determine bioaccessibility of PAHs.

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