Impaired HLA Class I Antigen Processing and Presentation as a Mechanism of Acquired Resistance to Immune Checkpoint Inhibitors in Lung Cancer

HLA I 类抗原加工和呈递受损是肺癌获得性免疫检查点抑制剂耐药的机制

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作者：Scott Gettinger, Jungmin Choi, Katherine Hastings, Anna Truini, Ila Datar, Ryan Sowell, Anna Wurtz, Weilai Dong, Guoping Cai, Mary Ann Melnick, Victor Y Du, Joseph Schlessinger, Sarah B Goldberg, Anne Chiang, Miguel F Sanmamed, Ignacio Melero, Jackeline Agorreta, Luis M Montuenga, Richard Lifton, So

期刊：

Cancer Discovery

影响因子：

29.700

时间：

2017

起止号：

2017 Dec;7(12):1420-1435.

doi：

10.1158/2159-8290.CD-17-0593

方法学：

研究方向：

信号转导、肿瘤

疾病类型：

肺癌

信号通路：

Checkpoint

Significance

As programmed death 1 axis inhibitors are becoming more established in standard treatment algorithms for diverse malignancies, acquired resistance to these therapies is increasingly being encountered. Here, we found that defective antigen processing and presentation can serve as a mechanism of such resistance in lung cancer. Cancer Discov; 7(12); 1420-35. ©2017 AACR.This article is highlighted in the In This Issue feature, p. 1355.

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