Single-cell magnetic imaging using a quantum diamond microscope

使用量子金刚石显微镜进行单细胞磁成像

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作者:D R Glenn #, K Lee #, H Park, R Weissleder, A Yacoby, M D Lukin, H Lee, R L Walsworth, C B Connolly

Abstract

We apply a quantum diamond microscope for detection and imaging of immunomagnetically labeled cells. This instrument uses nitrogen-vacancy (NV) centers in diamond for correlated magnetic and fluorescence imaging. Our device provides single-cell resolution and a field of view (∼1 mm(2)) two orders of magnitude larger than that of previous NV imaging technologies, enabling practical applications. To illustrate, we quantified cancer biomarkers expressed by rare tumor cells in a large population of healthy cells.

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