Abstract
Liposarcomas, the most common soft tissue tumors, occur predominantly in the lower limbs and retroperitoneum. Primary mediastinal liposarcomas are rare and account for <1% of mediastinal masses. We report a case of a large primary mediastinal liposarcoma invading the right ventricular outflow tract, pulmonary artery, and aortic adventitia that was successfully resected. This report highlights the complex nature of liposarcomas, given their tendency to invade critical structures.