Abstract
Intergenerational justice is the core principle supporting the legacy of benefit toward future generations, including the perpetuation of species and their genetic diversity, as a key component of biospheric sustainability. Thirty percent of Earth's terrestrial habitats are now undergoing protection, biodiversity hotspots are being targeted, and there is increasing community awareness and engagement in conservation. However, the impending sixth mass extinction threatens to drive many species to extinction in the wild, irrespective of these interventions. Earth's biosphere is now undergoing terraforming through ecosystem destruction and modification, urbanization, and agriculture. Therefore, transformative cultural, political, and economic incentives are needed to maximize the legacy of the Earth's biodiversity and biospheric sustainability toward future generations. Reproduction and advanced biotechnologies can perpetuate species and their genetic diversity while also contributing to human and animal health and agricultural production. Advanced reproduction biotechnologies, including genetic engineering and synthetic biology, provide a new horizon for biospheric management, through the de-extinction of ancient species, restoring recently lost species, and maintaining the genetic diversity of extant species through wildlife biobanking. More extensive and inclusive conservation breeding programs and wildlife biobanking resources/facilities are desperately needed to perpetuate more than 3,000 Critically Endangered terrestrial/freshwater species; a goal fully attainable for amphibians and smaller fishes through global inclusion of stakeholders including private caregivers, plausible for freshwater mussels and crayfish, in development for reptiles and birds, and applicable for many mammals. As this capacity develops, many otherwise neglected species that are losing their natural habitat can be perpetuated solely in biobanks, thus enabling the more efficient utilization of resources toward meaningful field conservation primarily through habitat protection. The full potential of reproduction and advanced biotechnologies includes the development of artificial wombs to address the human population crisis and to avoid surrogacy mismatching during species restoration or de-extinction. The use of advanced reproduction biotechnologies for direct human benefit, for species management, and for biospheric sustainability, are subject to evolving ethical and legal frameworks, particularly regarding genetic engineering, transhumanism, and the de-extinction of ancient species.