Abstract
OBJECTIVES: Oxidative stress and systemic inflammation are the main pathways by which air pollutants cause hypertension (HTN). Vitamin C intake may reduce the risk of HTN caused by air pollutants. This study aimed to investigate the association between air pollutants and pre-HTN and HTN in Korean adults and whether these associations were modified by vitamin C intake, using data from the 2013-2016 Korean National Health and Nutrition Examination Survey (KNHANES). DESIGN: Cross-sectional study. SETTING: This study used data from the KNHANES VI (2013-2015) and VII (2016) along with the data from the annual air pollution report of the Ministry of Environment. PARTICIPANTS: We included 11,866 adults who had responded to a semi-food frequency questionnaire. MEASUREMENTS: We used survey logistic regression models to evaluate the association of ambient PM10, SO2, NO2, CO, and O3 with pre-HTN and HTN according to vitamin C intake. RESULTS: After adjusting for potential covariates, exposure to ambient PM10, SO2, NO2, and CO was significantly associated with a high prevalence of pre-HTN and HTN, whereas exposure to O3 was significantly associated with a low prevalence of pre-HTN and HTN. In particular, as the air pollutant scores increased (severe air pollution), the prevalence of pre-HTN and HTN increased in a dose-dependent manner (highest score vs. lowest score, OR=1.85, 95% CI=1.39-2.46, p for trend <.0001). However, these associations were found to be pronounced in adults with low vitamin C intake (highest score vs. lowest score, OR=2.30, 95% CI=1.50-3.54, p for trend <.0001), whereas the statistical significance disappeared for adults with high vitamin C intake (highest score vs. lowest score, OR=1.40, 95% CI=0.93-2.12, p for trend=0.007). CONCLUSION: Exposure to air pollutants such as PM10, SO2, NO2, and CO may increase the prevalence of pre-HTN and HTN among Korean adults. In addition, a high intake of vitamin C may help prevent pre-HTN and HTN caused by air pollutants.