Cytotoxic and Luminescent Properties of Novel Organotin Complexes with Chelating Antioxidant Ligand

具有螯合抗氧化配体的新型有机锡配合物的细胞毒性和发光性质

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作者:Evgeny Nikitin, Ekaterina Mironova, Dmitry Shpakovsky, Yulia Gracheva, Daniil Koshelev, Valentina Utochnikova, Konstantin Lyssenko, Yury Oprunenko, Dmitry Yakovlev, Roman Litvinov, Mariya Seryogina, Alexander Spasov, Elena Milaeva

Results

the ligand itself demonstrated noticeable cytotoxicity while the introduction of organotin moiety either did not affect the toxicity levels or reduced them instead of increasing. Organotin complexes possess luminescence both as powders and DMSO solutions, its quantum yields reaching 67% in DMSO. The combination of luminescence with unique cytotoxic properties allows us to propose the synthesized compounds as perspective theranostic agents.

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