Clinical pharmacokinetics of antiretroviral drugs in Ugandan patients

乌干达患者抗逆转录病毒药物的临床药代动力学

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作者：Cohen,C,Davis,K,Meyers,J,Torpey,K,Ogbanufe,O,Babatunde,F,Mosuro,O,Fajola,A,Khamofu,H,Odafe,S,Barinaadaa,A,May,M,Gompels,M,Sabin,C,Moatti,J,El-Sadr,W,Maiese,E,Malmenäs,M,Atkinson,M,Fabbiani,M,Grima,P,Prosperi,M,Fanti,I,Colafigli,M,Zaccarelli,M,D'Avino,A,Mondì,A,Borghetti,A,Fantoni,M,Cauda,R,Di Giambenedetto,S,Jansson,J,Wilson,D,Carr,A,Petoumenos,K,Boyd,M,Fumaz,C,Muñoz-Moreno,J,Ferrer,M,Gonzalez-Garcia,M,Perez-Alvarez,N,Miranda,C,Negredo,E,Clotet,B,Moneti,V,Luís,N,Rijo,J,Miranda,A,Baptista,T,Farinha,H,Mansinho,K,Orrell,C,Levison,J,Ciaranello,A,Bekker,L,Kuritzkes,D,Freedberg,K,Wood,R,Reiss,P,Violari,A,Cotton,M,Otwombe,K,Hunt,G,Kalimashe,M,Panchia,R,Morris,L,Pillay,D,Babiker,A,Gibb,D,Perno,C,Murri,R,Fregosi,S,Bortolussi,P,Marcotullio,S,Maggiolo,F,Fasel,D,Kunze,U,Monsch,A,Battegay,M,Nichols,G,Mills,A,Grossberg,R,Lazzarin,A,Maggiolo,F,Molina,J,Pialoux,G,Wright,D,Ait-Khaled,M,Huang,J,Vavro,C,Wynne,B,Yeo,J,Sterrantino,G,Santoro,L,Trotta,M,Antinori,A,Bartolozzi,D,Zaccarelli,M,Antinori,A,Angeletti,C,Ammassari,A,Sangiorgi,D,Giannetti,A,Buda,S,Girardi,E,Degli Esposti,L,Gray,G,Sasse,A,Van Beckhoven,D,Redondo Sanchez,C,Poza Cisneros,G,Galera Peñaranda,C,Ruiz,C,Hernandez,A,Cascales,A,Rodriguez,F,Oliva,J,Friday,D,Evans-Jones,J,Steedman,N,Sabin,C,Elías Casado,L,Pérez Elías,M,López Pérez,D,Pumares Álvarez,M,Martinez-Colubi,M,Moreno Zamora,A,Muriel,A,Dronda,F,Marti-Belda,P,Gómez-Ayerbe,C,Rodriguez Sagrado,M,Moreno Guillén,S,Saag,M,Vera,J,Aragão,F,Guimaraes,M,Vaz Pinto,I,Lundgren,J,Mussini,C,Lawn,S,Estrada,V,Masiá,M,Iribarren,J,Sanchez-Marcos,C,Lozano,F,Miralles,C,Olalla,J,Santos,J,Bernardino,J,Dronda,F,Domingo,P,Bertagnolio,S,Parkin,N,Jordan,M,Ammassari,A,Gori,C,Pinnetti,C,Lorenzini,P,Zaccarelli,M,Pierro,P,Capobianchi,M,Perno,C,Antinori,A,Cooper,D,White,D,Aghar,S,Taylor,S,Cook,R,Hickinbottom,G,Berry,A,Robertson,C,Horne,R,Cooper,V,Lange,A,Vrijens,B,Palacios,R,Navarro,F,Moreno,T,Ruiz,J,Nuño,E,Márquez,M,Santos,J,Maggiolo,F,Fregosi,S,Bortolussi,P,Marcotullio,S,Murri,R,Palacios,R,Lebrón,J,Guerrero-León,M,Del Arco,A,Colmenero,J,Márquez,M,Santos,J,Chishinga,N,Godfrey-Faussett,P,Fielding,K,Grant,A,Schaap,A,Ayles,H,Casari,S,Bossini,N,Albini,L,Setti,G,Valerio,F,Izzo,I,Costarelli,S,Sandrini,S,Cancarini,G,Castelli,F,Patterson,P,Cahn,S,Sued,O,Fink,V,Figueroa,M,Cesar,C,Rojo,M,Ben,G,Vázquez,M,Cahn,P,Rodriguez-Guardado,A,Suarez,C,Fernandez,M,Rodriguez,M,Martinez,O,Rojo,S,Perez,F,Fink,V,Zurita,D,Tejo,M,Perez,H,Cesar,C,Figueroa,M,Patterson,P,Sued,O,Cahn,P,Martin,C,Castaigne,C,Tondeur,M,Flamen,P,De Wit,S,Cohen,M,Langebeek,N,Sprengers,H,Gisolf,E,Richter,C,Sprangers,M,Reiss,P,Nieuwkerk,P,Sibanda,E,Weller,I,Bernays,S,Hakim,J,Cowan,F,Mulcahy,F,Mazzotta,E,Agostinone,A,Sozio,F,Ursini,T,Polilli,E,Tontodonati,M,Tracanna,E,Placido,G,Pieri,A,Consorte,A,Cacciatore,P,Di Masi,F,Calella,G,Falorio,S,Leva,M,Vizioli,M,Angrilli,F,Manzoli,L,Parruti,G,Lamorde,M
期刊：Journal of the International Aids Society影响因子：4.900
时间：2012起止号：2012;15(Suppl 4):18060-301
doi：10.7448/IAS.15.6.18060

Abstract

Clinical pharmacokinetic data on antiretroviral drugs are scarce in African HIV-1-positive patients. Most available pharmacokinetic data are derived from ethnically distinct Caucasian research volunteers. This presentation will focus on the clinical pharmacokinetics training and research outputs of an HIV Research Trust scholarship recipient in Uganda. The work highlights the need for post-marketing pharmacokinetic studies in the target populations in order to optimize therapy for patients in resource-limited settings.

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