Abstract
PURPOSE: To investigate the multi-slice spiral Computed Tomography(MSCT) findings of chest involvement in IgG4-related diseases and to improve doctors' understanding of this disease. MATERIALS AND METHODS: We retrospectively analyzed the clinical and imaging data of 67 patients with clinically confirmed or suspected IgG4-related diseases. RESULTS: Sixty patients (89.60%) had abnormal chest CT findings. Among them, 47 patients (70.10%) had enlarged mediastinal lymph nodes. Thickening of the tracheal and tracheobronchial perivascular walls was observed in 35 patients (52.20%). Nodules were observed in 29 patients (43.30%). Patches or ground-glass opacities were observed in 15 cases (22.40%); bilateral enlarged axillary lymph nodes, 9 (13.40%); bilateral enlarged hilar lymph nodes, 3 (4.50%); and, interstitial changes, 3 (11.90%). Pleural and pericardial effusion occurred in five cases (7.46%, two bilateral and three unilateral) and three cases (4.50%), respectively. Seven (10.45%) patients showed no obvious abnormalities. The abnormally elevated IgG4 level (>135 mg/dL) was positively correlated with thickening of the tracheal and tracheobronchial walls (r = 0.328, p = 0.007) and enlargement of mediastinal lymph nodes (r = -0.252, p = 0.039), and the logistic regression model 1 showed that the incidence of lung as the first symptom was higher in patients with bilateral enlarged hilar lymph nodes on chest images. CONCLUSION: Chest CT is of great significance for the diagnosis and follow-up of IgG4-RLD. Chest CT scans should be suggested to be performed when ocular symptoms, bilateral enlarged hilar lymph nodes, pancreatitis, pituitary adenitis, Takayasu arteritis, or abnormally elevated IgG4 levels (>135 mg/dL) are present, and IgG4-RLD should be considered.