Conclusion
The increase of serum MIP-1α level is relevant to the condition and prognosis of NRDS children. The level of cord blood MIP-1α level is expected to become a potential outcome measure.
Methods
In this retrospective analysis, 96 newborns with NRDS in Affiliated Lianyungang Hospital of Xuzhou Medical University from January 2018 to June 2021 were included in the experimental group (EG), while the other 60 normal neonates were included as the control group (CG). The concentration of MIP-1α in umbilical cord blood was tested by Elisa method. The clinical value of MIP-1α in diagnosing NRDS was assessed via receiver operating characteristic (ROC) curve. According to the 28-day survival data, children were divided into a survival group and a death group. The prognostic factors were assessed by Cox regression analysis. The correlation between MIP-1α and IL-1β, IL-6, TNF-α, SNAPPE-II scores were evaluated by Pearson test. The relationship between the MIP-1α level and the severity of the disease was assessed.
Objective
To investigate the expression and prognostic value of macrophage inflammatory protein 1α (MIP-1α) in neonatal acute respiratory distress syndrome (NRDS).
Results
The MIF-1α level in cord blood of children in the EG was dramatically higher than that in the CG (P<0.05). Besides, ROC curve further found that the area of MIF-1α under the curve of diagnosing NRSD was 0.949. MIF-1α was positively correlated with the levels of interleukin-1β (IL-1β), interleukin-6 (IL-6), tumor necrosis factor α (TNF-α) and SNAPPE-II score (P<0.001). With the increase of NRDS, the serum MIF-1α level increased, showing a positive association (P<0.05). Cox regression analysis revealed that the severity and MIF-1α level were independent prognostic factors of survival (P<0.001). The survival rate of children with MIF-1α <281.58 pg/mL as well as children with I-II grade was higher than those with MIF-1α >281.58 pg/mL as well as children with III-IV grade (P<0.05).