Abstract
This issue of the Biomedical Journal puts an emphasis on inflammasome subunits, the NLR protein family, and the role they play in immunity. CIITA is presented as promising tool for augmenting tumor immunogenicity. Several articles look into the involvement of NLRP3 in inflammatory bowel disease and changes of the gut microbiome, in blood glucose management, in sterile inflammation, and NLRP3's contribution to the development of hepatic encephalopathy. Furthermore, a review concerning small cell neuroendocrine carcinoma of the cervix is presented, insights are provided as to the association of knee pain and patellar malalignment, and the connection between hypoxia and sleep apnea in the case of liver injury is elucidated. Additional articles illuminate the challenge of predicting influenza infections; show how ctDNA may serve as predictor for survival outcome in ovarian carcinoma; and lastly soft tissue changes after bimaxillary rotational surgery are assessed.