From form to function: m6A methylation links mRNA structure to metabolism

从形式到功能:m6A 甲基化将 mRNA 结构与代谢联系起来

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作者:Braulio Martinez De La Cruz, Marousa Darsinou, Antonella Riccio

Abstract

Reversible N6-methyladenosine (m6A) RNA modification is a posttranscriptional epigenetic modification of the RNA that regulates many key aspects of RNA metabolism and function. In this review, we highlight major recent advances in the field, with special emphasis on the potential link between m6A modifications and RNA structure. We will also discuss the role of RNA methylation of neuronal transcripts, and the emerging evidence of a potential role in RNA transport and local translation in dendrites and axons of transcripts involved in synaptic functions and axon growth.

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