Abstract
COVID-19 is a highly transmissible infectious disease that remains a substantial challenge. The utilization of chest radiology, particularly X-ray imaging, has proven to be highly effective, easily accessible, and cost-efficient in detecting COVID-19. A dataset named COVID-Xray-5k, consisting of imbalanced X-ray images of COVID-19-positive and normal subjects, is employed for investigation. The research introduces a novel methodology that utilizes conventional machine learning (ML), such as local binary patterns (LBP) for feature extraction and support vector machines (SVM) for classification. In addition, transfer learning is employed with the Visual Geometry Group 16-layer (VGG16) and 19-layer (VGG19) models. Besides, novel sequential convolutional neural network (CNN) architectures are presented to develop an autonomous system for classifying COVID-19. One of the proposed CNN architectures classifies the test dataset with an F1 score of 91.00% and an accuracy of 99.45% based on an empirical investigation to determine optimal hyper-parameters. The methods presented in the research show promising potential for COVID-19 classification, irrespective of class imbalance.•Employment of ML models to investigate subjective feature engineering and classification.•Transfer learning was employed for VGG16 and VGG19 with eight distinct models.•Illustration of two novel CNN sequential architectures; all the investigation is performed with and without weighted sampling.