Abstract
Managing advanced heart failure (HF) remains a major clinical challenge, especially for patients who no longer respond to conventional treatment options, or are not candidates for heart transplantation. In such cases, left ventricular assist devices (LVADs) have become an important option, offering mechanical support that has the potential to extend life and improve daily functioning. With ongoing advancements in technology, there is growing interest in understanding how LVADs impact not just survival, but also patients' quality of life (QoL) and overall recovery. This narrative review explores the role of LVAD therapy in improving functional status and QoL in patients with advanced HF. It draws on clinical research from the past 15 years to examine physical, psychological, and social outcomes, as well as the challenges and complications associated with this treatment. A structured PubMed search was performed using predefined MeSH terms and keywords related to LVADs. After removing duplicates, 68 articles were identified. Eleven reviewers screened titles and abstracts, followed by full-text review and data extraction. Studies were included if they involved adults, were conducted in the past 15 years, and used clinical or observational study designs. Non-English, pediatric, and pregnancy-related studies were excluded. A total of 44 studies met the criteria. LVADs were associated with improvements in physical function, exercise capacity, and QoL. However, patients often faced psychological stress and medical complications. Better pre-implant health and strong support systems contributed to more favorable outcomes. LVADs offer meaningful improvements in both survival and QoL, but holistic, patient-centered care remains key to optimizing outcomes.