Early identification and multidisciplinary management of immune checkpoint inhibitors associated colitis can improve patient outcomes

早期识别和多学科管理免疫检查点抑制剂相关性结肠炎可以改善患者预后。

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Abstract

Currently, the use of immune checkpoint inhibitors (ICIs) has shown notable clinical efficacy in treating various malignant tumors, significantly improving patient prognosis. However, while ICIs enhance the body's anti-tumor effects, they can also trigger immune-related adverse events (irAEs), with ICI-associated colitis being one of the more prevalent forms. This condition can disrupt treatment, necessitate drug discontinuation, and adversely affect therapeutic outcomes. In severe cases, irAEs may even become life-threatening. A recent case report by Hong et al highlights the importance of vigilance for ICI-associated colitis in patients experiencing symptoms such as diarrhea and abdominal pain, which can arise both during and even after completion of ICI treatment. Early identification, multidisciplinary management, and continuous monitoring of patients are essential steps to further improve outcomes.

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