Abstract
The clinicians remain uncertain about the ideal timing for loop ileostomy reversal following rectal resection surgery. The common practice of waiting 8-12 weeks to protect from anastomotic complication, especially in patients who receive neoadjuvant chemoradiotherapy, would expose patients to dehydration, electrolyte disturbances, stoma related complications, and reduced quality of life. Randomized controlled trials have studied early reversal of ileostomy, with results ranging from improved outcomes in selected patients to increased morbidity when applied indiscriminately. Meta-analyses have also yielded heterogeneous findings, reflecting the need for careful patient selection. The study by Özcan and Düzgün used retrospective methods to show that patients who underwent early closure experienced similar complication rates to those who had late closure, but early closure were associated with better quality of life. Taken together, current evidence suggests that reversal within 2-4 weeks may be safe and beneficial in meticulously selected patients with an intact anastomosis and an uneventful postoperative course. Their study provides practical data supporting early closure. It is limited, however, by being retrospective with a short follow-up period, which may leave important concerns unaddressed. Multicenter randomized trials are required to help establish safe standardized criteria for early closure and long-term safety.