Abstract
Animal models are poised to make key contributions to the study of cognitive deficits associated with chronic cocaine use in people. Advantages of animal models include use of a longitudinal experimental design that can control for drug use history and onset-age, sex, drug consumption, and abstinence duration. Twenty-two studies were reviewed (13 in adult male rats, 5 in adolescent vs. adult male rats, 3 in adult male monkeys, and 1 in adult female monkeys), and it was demonstrated repeatedly that male animals with adult-onset cocaine self-administration exposure had impairments in sustained attention, decision making, stimulus-reward learning, working memory, and cognitive flexibility, but not habit learning and spatial learning and memory. These findings have translational relevance because adult cocaine users exhibit a similar range of cognitive deficits. In the limited number of studies available, male rats self-administering cocaine during adolescence were less susceptible than adults to impairment in cognitive flexibility, stimulus-reward learning, and decision making, but were more susceptible than adults to impairment in working memory, a finding also reported in the few studies performed in early-onset cocaine users. These findings suggest that animal models can help fill an unmet need for investigating important but yet-to-be-fully-addressed research questions in people. Research priorities include further investigation of differences between adolescents and adults as well as between males and females following chronic cocaine self-administration. A comprehensive understanding of the broad range of cognitive consequences of chronic cocaine use and the role of developmental plasticity can be of value for improving neuropsychological recovery efforts.