Abstract
The last 4 decades have seen an explosion in nutritional research investigating both clinical and laboratory issues occurring in diverse groups of patients who cannot maintain a normal oral diet. Over the past 25 years, researchers have investigated how the administration of macro- and micronutrients via the gastrointestinal tract provides additional benefit over parenteral administration of similar nutrients. The administration of enteral feeding provides effects that are far beyond those of merely administering macro- and micronutrients. Rather, the processing of nutrients via the gastrointestinal tract stimulates a complex response that has implications for body composition and for immunologic integrity. Route and type of nutrition are important aspects of successful patient recovery.