Abstract
In the current study, bi-metal oxide hybrid nanocomposites prepared by cerium oxide (CeO(2) ) nanoparticles are included into chitosan-ZnO composites for developing the potential materials of dressing the wound. The wound healing effect of prepared hybrid nanocomposites was evaluated regarding the surface morphology, functional groups, thermal degradation and composite size. The antimicrobial activity of chitosan-ZnO/CeO(2) hybrid nano composites was tested against the pathogens of Staphylococcus aureus and Escherichia coli. The hybrid nanocomposites containing CeO(2) -based chitosan and ZnO nanoparticles were taken for optimum dressing included in the vivo studies on the excisional wounds in wistar rats. After 2 weeks, it is seen that the wound treated with CS-ZnO/CeO(2) hybrid nano composites consists of the significant dressing of nearly 100% compared with control which showed nearly 65% of wound closure. Finally, our reported results gave the proof in supporting the availability of CS-ZnO/CeO(2) hybrid nanocomposites contains the dressing of the wounds for the treatment.