Abstract
Advancements in fracture fixation have significantly reshaped orthopedic trauma management by improving mechanical stability and promoting biological healing. This retrospective observational study assessed clinical and biomechanical outcomes in 500 patients who underwent surgical fixation for radiologically confirmed fractures. Patients were categorized into two groups: Group A received conventional fixation methods (e.g., standard plates and screws), while Group B was treated with advanced systems, including locking plates, intramedullary nails, minimally invasive percutaneous osteosynthesis (MIPO), and bioresorbable implants. Data analysis included 50 variables spanning demographics, clinical profiles, imaging, laboratory results, implant details, and postoperative outcomes. Statistical methods such as t-tests, chi-square, Mann-Whitney U, Kruskal-Wallis, Kaplan-Meier survival analysis, and multiple regression models were performed using IBM SPSS Statistics for Windows, Version 27.0 (Released 2019; IBM Corp., Armonk, NY, US). The study found that advanced fixation techniques resulted in significantly faster healing (12.4 vs. 14.9 weeks, p < 0.001), earlier mobilization (p = 0.003), and better three-month functional outcomes, with 80.1% in Group B achieving good to excellent recovery compared to 58.2% in Group A (p < 0.001). The complication rate was notably lower in the advanced group (10.8% vs. 20.4%, p = 0.003). Regression analysis identified implant type, vitamin D levels, and diabetes status as key predictors of healing duration, complication risk, and functional recovery. Predictive models demonstrated strong performance: a linear regression model for healing time (R² = 0.38, p < 0.001), a logistic regression model for complications (accuracy = 71.6%), and an ordinal regression model for functional outcomes (Nagelkerke R² = 0.41, p < 0.001). These findings support the clinical benefits of modern fixation systems and highlight the importance of integrating biomechanical choices with patient-specific health indicators to enhance fracture management outcomes.