Prevalence and Risk Factors of Neonatal Covid-19 Infection: A Single-Centre Observational Study

新生儿新冠病毒感染的患病率和危险因素:一项单中心观察性研究

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Abstract

BACKGROUND: This study is to estimate the prevalence and to determine the risk factors for neonatal Covid-19 infection. METHODS: Retrospective analysis of all deliveries in Covid-19-infected mothers in a tertiary care centre in North Kerala from 15 April 2020 to 15 October 2020. RESULTS: Of the 350 Covid-19-positive pregnancies 223 delivered, two were intrauterine foetal demises. In total, 32 out of 221 newborns were Covid-19-positive (14.47%). The risk was more in vaginal delivery group (17.39%) compared to caesarean group (13.16%). The breastfeeding and rooming-in group (18.79%) had more infection than those babies who were not breastfed and separated from mother (1.78%).14 out of 86 (16.28%) babies delivered within 7 days of mothers turning negative became positive compared to 2 out of 23 (8.7%) babies delivered between 7 and 14 days of negative result (Odds ratio of 2.04). None of the babies delivered 14 days after negative result has become positive. CONCLUSIONS: The present study shows that neonatal Covid-19 infection is not rare. The risk is greater in vaginal delivery group and those babies who are breastfed and allowed to stay with mothers. Delaying delivery more than 7 days after mother becoming negative protects the newborn from getting infection.

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