Discussion
This novel device for inducing TBI may be a valuable alternative for modeling brain injury and studying its consequences.
Methods
In this study, we present a novel device called the Hydro-pneumatic Fluid Percussion Device, which delivers fluid directly to a lateral region of the brain to induce injury. To validate this model, three groups of male and female rats were subjected to lateral fluid percussion using our device, and the resulting damage was evaluated using sensory, motor, and cognitive tests, measurements of serum injury biomarkers, and morphological analysis via cresyl violet staining.
Results
Our results demonstrate that this new approach induced significant alterations in all parameters evaluated.