Abstract
INTRODUCTION: Immune reconstitution inflammatory syndrome (IRIS) is closely associated with antiretroviral therapy (ART) and poses a clinical challenge in HIV management. CASE PRESENTATION: This report describes an HIV-infected individual who developed Primary immune thrombocytopenia, latent autoimmune diabetes in adults, and Hashimoto thyroiditis after starting ART. CONCLUSION: Antiretroviral therapy (ART) may result in thrombocytopenia, fluctuations in blood glucose levels, thyroid dysfunction, diabetic ketoacidosis (DKA), or thyroid crisis. Healthcare professionals should evaluate the potential links between immune reconstitution inflammatory syndrome (IRIS) and latent autoimmune diabetes in adults (LADA), immune thrombocytopenia (ITP), as well as Hashimoto thyroiditis (HT).