Abstract
Elizabethkingia anophelis is an opportunistic pathogen that causes serious life-threatening infections. In this report, we describe a case of pulmonary infection caused by E. anophelis in a young female patient, following cardiac surgery, which was successfully treated with a combination of trimethoprim-sulfamethoxazole (TMP-SMZ) and eravacycline. Additionally, this report provides a summary of high-risk factors for E. anophelis infection, clinical manifestations, and therapeutic options. Given the high degree of antimicrobial drug resistance of the organism and the fact that inappropriate empirical antimicrobial therapy constitutes a risk factor for mortality, our case serves as a valuable reference for similar cases, highlighting potential strategies for effective management.