Case Report of bla (NDM-7)-Harboring IncX3 Plasmid in ST196 Klebsiella quasipneumoniae in China

中国一例携带bla(NDM-7)基因的IncX3质粒的ST196型肺炎克雷伯菌病例报告

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Abstract

Klebsiella quasipneumoniae isolate SBH035 was recovered from a patient in Jiangsu Province, China. The isolate showed resistance to ampicillin, cefazolin, cefotaxime, meropenem, ceftazidime-avibactam, and fosfomycin. The carbapenemase-encoding gene bla (NDM-7) was identified, and whole genome sequencing analysis indicated that bla (NDM-7) was located in an IncX3 plasmid with a conserved structure of IS26-ΔcutA-tat-trpF-ble (MBL) -bla (NDM-7)-ISAba125-IS3000-ΔTn2. To date, this is the first identification of a bla (NDM-7)-harboring IncX3 plasmid in ST196 K. quasipneumoniae from a patient in China. Greater attention to controlling the dissemination of IncX3 plasmids is needed owing to potential horizontal transfer via mobile genetic elements.

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