Peribiliary Glands Are Key in Regeneration of the Human Biliary Epithelium After Severe Bile Duct Injury

胆管周围腺体是严重胆管损伤后人类胆管上皮再生的关键

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作者:Iris E M de Jong, Alix P M Matton, Jasper B van Praagh, Wouter T van Haaften, Janneke Wiersema-Buist, Louise A van Wijk, Dorenda Oosterhuis, Raditya Iswandana, Su Suriguga, Diletta Overi, Ton Lisman, Guido Carpino, Annette S H Gouw, Peter Olinga, Eugenio Gaudio, Robert J Porte

Conclusion

Human PBG contain biliary progenitor cells and are able to respond to bile duct epithelial loss with proliferation, differentiation, and maturation to restore epithelial integrity. The ex vivo spatiotemporal behavior of human PBG cells provides evidence for a pivotal role of PBG in biliary regeneration after severe injury.

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