Growth hormone replacement therapy regulates microRNA-29a and targets involved in insulin resistance
生长激素替代疗法调节 microRNA-29a 和与胰岛素抵抗有关的靶点
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作者：Artur Galimov, Angelika Hartung, Roman Trepp, Alexander Mader, Martin Flück, Axel Linke, Matthias Blüher, Emanuel Christ, Jan Krützfeldt
Key messages
GHRT most significantly affects the ECM cluster in skeletal muscle from mice. GHRT downregulates miR-29a and upregulates miR-29a targets in skeletal muscle from mice. PTEN, COL3A1, FSTL1, SERPINH1, and SPARC are endogenous miR-29a targets in human myotubes. IGF1 decreases miR-29a levels in human myotubes. miR-29a and its targets are regulated during GHRT in skeletal muscle from humans.
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