Abstract
BACKGROUND: The presence of NO as a marker of airway inflammation and indirectly as a general indicator of inflammation and oxidative stress-incrimination as incriminating factor in lung cancer at an early stage and then the treatment of disease after chemotherapy. PATIENTS AND METHODS: Studied whether exhaled NO levels altered by 3 cycles of chemotherapy the levels at diagnosis and whether directly or indirectly related to the course of disease. Also, correlation levels of NO with other markers of inflammation. We studied 42 patients early diagnosed -26 men and 16 women with lung cancer. We analysed blood tests for control of inflammatory markers, functional pulmonary tests and alveolar exhaled nitric oxide. RESULTS: Recorded decrease in exhaled NO after 3 cycles of chemotherapy in all patients regardless of histological type and stage. 42 patients with a mean 9.8 NO occurs after 3 cycles average 7.7. Also appears strong correlation between NO before and after chemotherapy and CRP (P<0.05, pre chemotherapy) and (P<0.045, after chemotherapy). It is a further breakdown of data by the statistical program SPSS, with subgroups for analysis based histological types (Table 3). CONCLUSIONS: NO alveolar as an indicator of airway inflammation, indicates response to chemotherapy in lung cancer .Also the inflammatory process in lung cancer confirmed and indicates response to chemotherapy through an index which is sensitive to inflammatory diseases of the airways and not reused in lung cancer before and after chemotherapy.