Abstract
Genes Dev (2012) 26, 2286–2298 doi:; DOI: 10.1101/gad.195545.112; September 26 2012 Cell Stem Cell (2012) 11, 477–490 doi:; DOI: 10.1016/j.stem.2012.08.002; October 05 2012 Cell Stem Cell (2012) 11, 491–504 doi:; DOI: 10.1016/j.stem.2012.06.008; October 05 2012 The orphan nuclear receptor estrogen-related receptor b (Esrrb) is a vital component of the core pluripotency network in embryonic stem cells (ESCs). However, its function is not clear and the identity of potential upstream regulators has remained elusive. Three elegant reports (Festuccia et al, 2012; Martello et al, 2012; Percharde et al, 2012) have now elucidated the role of Esrrb in ESC self-renewal and reprogramming.