Phosphate-induced ORAI1 expression and store-operated Ca2+ entry in aortic smooth muscle cells
磷酸盐诱导的 ORAI1 表达和主动脉平滑肌细胞中的池操纵 Ca2+ 内流
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作者:Ke Ma, Ping Liu, Tamer Al-Maghout, Basma Sukkar, Hang Cao, Jakob Voelkl, Ioana Alesutan, Burkert Pieske, Florian Lang
Key messages
• In aortic SMC, phosphate donor ß-glycerophosphate upregulates Ca2+ channel ORAI1. • In aortic SMC, ß-glycerophosphate upregulates ORAI1-activator STIM1. • In aortic SMC, ß-glycerophosphate upregulates store-operated Ca2+-entry (SOCE). • The effect of ß-glycerophosphate on SOCE is disrupted by ORAI1 inhibitor MRS1845. • Stimulation of osteogenic signaling is disrupted by MRS1845 and ORAI1 silencing.
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