Non-invasive brain stimulation and computational models in post-stroke aphasic patients: single session of transcranial magnetic stimulation and transcranial direct current stimulation. A randomized clinical trial

中风后失语症患者的非侵入性脑刺激和计算模型:单次经颅磁刺激和经颅直流电刺激。一项随机临床试验

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作者:Michele Devido Dos Santos, Vitor Breseghello Cavenaghi, Ana Paula Machado Goyano Mac-Kay, Vitor Serafim, Alexandre Venturi, Dennis Quangvinh Truong, Yu Huang, Paulo Sérgio Boggio, Felipe Fregni, Marcel Simis, Marom Bikson, Rubens José Gagliardi

Conclusions

The present study did not show any statistically significant difference between tDCS, TMS and sham stimulation regarding naming tasks. The patients'responses to the computational model showed different patterns of current distribution.

Methods

Patients with aphasia received one session of tDCS, TMS or sham stimulation. The time taken to name pictures and the response time were evaluated before and after neuromodulation. Selected patients from the first intervention underwent a computational model stimulation procedure that simulated tDCS.

Objective

Patients undergoing the same neuromodulation protocol may present different responses. Computational models may help in understanding such differences. The aims of this study were, firstly, to compare the performance of aphasic patients in naming tasks before and after one session of transcranial direct current stimulation (tDCS), transcranial magnetic stimulation (TMS) and sham, and analyze the

Results

The results did not indicate any statistically significant differences from before to after the stimulation.The computational models showed different current flow distributions. Conclusions: The present study did not show any statistically significant difference between tDCS, TMS and sham stimulation regarding naming tasks. The patients'responses to the computational model showed different patterns of current distribution.

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