Antibody-Drug Conjugate αEGFR-E-P125A Reduces Triple-negative Breast Cancer Vasculogenic Mimicry, Motility, and Metastasis through Inhibition of EGFR, Integrin, and FAK/STAT3 Signaling

抗体-药物偶联物 αEGFR-E-P125A 通过抑制 EGFR、整合素和 FAK/STAT3 信号传导降低三阴性乳腺癌血管生成拟态、运动和转移

阅读:7
作者:Ankita P Sankar, Hyun-Mi Cho, Seung-Uon Shin, Tal Sneh, Sundaram Ramakrishnan, Christian Elledge, Yu Zhang, Rathin Das, Hava Gil-Henn, Joseph D Rosenblatt

Significance

αEGFR-E-P125A reduces VM, angiogenesis, tumor growth, and metastasis by inhibiting EGFR and α5β1 integrin signaling, and is a promising therapeutic agent for TNBC treatment, used alone or in combination with chemotherapy.

特别声明

1、本页面内容包含部分的内容是基于公开信息的合理引用;引用内容仅为补充信息,不代表本站立场。

2、若认为本页面引用内容涉及侵权,请及时与本站联系,我们将第一时间处理。

3、其他媒体/个人如需使用本页面原创内容,需注明“来源:[生知库]”并获得授权;使用引用内容的,需自行联系原作者获得许可。

4、投稿及合作请联系:info@biocloudy.com。