Abstract
Ankle sprains are a common injury among athletes and the general population, with chronic ankle instability (CAI) being a frequent complication. CAI patients often display altered neuromuscular control adaptations. This study analyzed muscle synergy patterns in 20 CAI patients during anticipated and unanticipated landing tasks to understand their neuromuscular adaptation strategies. Using Nesterov non-negative matrix factorization and K-means clustering, the study identified distinct muscle activation patterns. Results indicated that during unanticipated landings, the gluteus maximus and vastus lateralis showed increased activation weight, while the medial gastrocnemius was more active in anticipated landings. This study highlights that CAI patients display unique muscle synergy patterns during unanticipated landings, relying more on proximal muscles such as the gluteus maximus and vastus lateralis. This adaptation reflects the proximal muscle strategy to enhance stability and compensate for impaired ankle function in unpredictable situations.