Abstract
Under most conditions, loop diuretics are K(+)-wasting, requiring potassium supplementation. In this issue, Wang and colleagues demonstrate that in mice fed a low-Na(+), high-K(+) diet, loop diuretics, in contrast, are K(+)-sparing. This observation suggests that possible elevations in plasma K(+) should be monitored when using a loop diuretic with a low-Na(+), high-K(+) diet, particularly when in combination with a potassium supplement.