Abstract
Non-small cell lung cancer (NSCLC) with chest wall invasion is typically diagnosed at initial presentation, and nodal involvement (especially N2 station) correlates with poor prognosis. To our knowledge, this is the first report of a solitary squamous cell carcinoma of the right chest wall arising 21 months after video-assisted thoracoscopic surgery (VATS) lobectomy for left NSCLC (pT1bN0M0). Primary solitary chest wall squamous cell carcinoma in adults is poorly documented, with limited data on its clinical manifestations, pathology, and management. This case aims to enhance understanding of this rare entity, aiding in avoiding misdiagnosis and inappropriate treatment (Yin et al. in Med (Baltim) 2018;97(44):e13112).