Abstract
OBJECTIVE: This study aims to systematically explore the development pattern and influence of nanozyme technology in the field of oncology diagnosis and treatment through bibliometric analysis methods, while identifying which countries are the innovation drivers in this field. METHODS: On October 16, 2024, a search of the Web of Science Core Collection (WoSCC) was conducted to review and analyze the application of nanozymes in oncology. A total of 977 studies published from 2007 to 2024 were retrieved and examined. RESULTS: We found that global research interest and publication volume related to this topic continue to rise. China leads in international cooperation, publication volume, and citation frequency, highlighting its outstanding position in this field. The Chinese Academy of Sciences is the largest contributing institution in terms of publication volume. Notably, ACS Applied Materials & Interfaces and Advanced Healthcare Materials are the 2 most popular journals in this field. In authors, Yang, Piaoping leads with 25 articles, and Qu, Xiaogang is the most cited author. The keyword co-occurrence network reveals 3 hotspots: "nanozymes," "photodynamic therapy," and "peroxidase-like activity"; "cell-death," "strategies," "recent progress," and "catalyst" are identified as trend topics for future exploration. CONCLUSION: Nanozymes hold significant promise for cancer diagnostics and therapy, with China, the United States, and Singapore leading the way in innovative research within this domain. Moving forward, research efforts should focus on fostering global collaboration and interdisciplinary synergy, innovate in the development of new nanozyme materials like SAzymes to improve catalytic performance and safety, investigate the potential role of nanozymes in cancer immunotherapy, and expedite the progression of nanozyme technologies from experimental settings to clinical use.