Abstract
INTRODUCTION: Frailty is common among older patients with cancer and may influence treatment outcomes. This study evaluated frailty prevalence and its association with unplanned hospitalizations in adult cancer patients. MATERIALS AND METHODS: We prospectively included 2081 patients with newly diagnosed cancer from 3 medical centers in Taiwan (2018-2022) who were scheduled to undergo cancer treatment. Frailty was assessed using a comprehensive geriatric assessment within 7 days before treatment initiation. Patients were categorized as fit, pre-frail, or frail to assess the impact on 90-day unplanned hospitalization. RESULTS: The prevalence of fit, pre-frail, and frail patients was 16.7%, 32.2%, and 51.0%, respectively. Frailty was associated with older age, unmarried status, lower education, unemployment, poor ECOG performance status, cancer site, and advanced stage (all P < .001). Core contributors to frailty across cancer sites included malnutrition, comorbidity, and polypharmacy. Functional impairment was prominent in patients with gastrointestinal, hematologic, and genitourinary cancers, while cognitive impairment was notable in those with genitourinary cancers. Unplanned hospitalization rates were highest in the frail group (41.5%), followed by pre-frail (34.4%) and fit (25.9%) patients. Frailty remained independently associated with unplanned hospitalizations after adjustment: pre-frail (adjusted odds ratio [OR] 1.44; 95% CI 1.06-1.94; P = .018) and frail (OR 2.07; 95% CI 1.55-2.76; P < .001). CONCLUSION: Frailty was prevalent and significantly associated with increased risk of unplanned hospitalization. These findings support the integration of frailty screening in routine oncology care to guide clinical decisions for vulnerable cancer patients.