Abstract
The horizontal ascending ramus of the lateral fissure (half) is a characteristic sulcus of the ventrolateral frontal cortex that forms the morphological boundary between the pars triangularis and the pars orbitalis of the inferior frontal gyrus. The present study examined the morphology of this sulcus to provide a means of identifying it accurately with magnetic resonance imaging (MRI). Voxels within the half were labeled in 50 in vivo MRI volumes (1.5 T) that had been linearly registered to the Montreal Neurological Institute stereotaxic space and the morphology of the half was categorized based on relations with neighboring sulci. The spatial variability and extent of the half were then quantified across subjects using volumetric (MINC Toolkit) and surface (FreeSurfer) spatial probability maps. The half could be identified in 95% of hemispheres, and the main morphological patterns were classified into three categories: Types I, II, and III. There were no statistically significant interhemispheric differences in the frequency of the half or its morphological patterns. Understanding the details of the sulcal morphology of this ventrolateral region is critical for an accurate interpretation of the location of activation peaks generated in functional neuroimaging studies investigating language, working memory, and other cognitive processes.