Abstract
Growing evidence suggests that PM(2.5) is associated with diabetes mellitus (DM). Although DM is a major public health concern, there has not yet been a study of this association in Japan. We used health examination data from 66,885 individuals in Tokyo, Japan 2005-2019. Cox proportional hazards models were used to evaluate an association between annual exposure to PM(2.5) and glycated hemoglobin A(1c) (HbA(1c)), or fasting plasma glucose (FPG). An increase of 1 μg/m(3) in the annual average of PM(2.5) concentration was associated (HR = 1.029; 95% CI = 1.004-1.055) with an increase in diabetes (incident + prevalent). For incident DM, a greater PM(2.5) level was associated with more DM (HR = 1.029; 95% CI, 1.003-1.055). Compared to HbA(1c), FPG showed a stronger association with the annual exposure to PM(2.5) (HR = 1.065; 95% CI, 1.040-1.091). We found that greater exposure to PM(2.5) in the long-term was associated with an increased risk of diabetes, and that the magnitude of association became stronger as the exposure duration increased. Omorogieva Ojo.