Reliable set-up for in-loop ¹¹C-carboxylations using Grignard reactions for the preparation of [carbonyl-¹¹C]WAY-100635 and [¹¹C]-(+)-PHNO

利用格氏反应进行环内¹¹C羧化反应，制备[羰基-¹¹C]WAY-100635和[¹¹C]-(+)-PHNO，建立了可靠的装置。

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作者：Rami-Mark,Christina,Ungersboeck,Johanna,Haeusler,Daniela,Nics,Lukas,Philippe,Cecile,Mitterhauser,Markus,Willeit,Matthaeus,Lanzenberger,Rupert,Karanikas,Georgios,Wadsak,Wolfgang
期刊：Applied Radiation and Isotopes影响因子：1.800
时间：2013起止号：2013 Dec;82:75-80
doi：10.1016/j.apradiso.2013.07.023

Abstract

Aim of this work was the implementation of a generalized in-loop synthesis for (11)C-carboxylations and subsequent (11)C-acylations on the TRACERlab FxC Pro platform. The set-up was tested using [carbonyl-(11)C]WAY-100635 and, for the first time, [(11)C]-(+)-PHNO. Its general applicability could be demonstrated and both [carbonyl-(11)C]WAY-100635 and [(11)C]-(+)-PHNO were prepared with high reliability and satisfying outcome.

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