Conjugated Nitroolefins as Twofold Electrophiles for the Assembly of Five-Membered Monoheterocycles via MIRC [3+2] Annulation: An Update on Synthetic and Mechanistic Aspects

共轭硝基烯烃作为双重亲电试剂通过MIRC [3+2]环化反应组装五元单杂环:合成和机理方面的最新进展

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Abstract

Five-membered monoheterocycles, either isolated or embedded in more complex systems, are ubiquitous structural motifs in nature and hence privileged targets of synthetic chemistry. Among a plethora of methodologies used for their assembly, [3+2] annulation strategies keep attracting particular interest among chemists, partly because of some significant characteristics from both the operative and the environmental viewpoints. Herein, the extensive use of conjugated nitroolefins as twofold electrophilic, two-carbon components of [3+2] MIRC (Michael-Initiated Ring Closure) annulations is reviewed as a practical and mechanistic update covering the last decade (2015-2025).

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